Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing

How I Do It: Genetic counseling and genetic testing for inherited prostate cancer.

Prostate cancer has a substantial heritable component, which is often under-appreciated in the urologic community. Inherited prostate cancer which may account for up to 10% of cases has been associated with genetic mutations which are also linked with other hereditary cancer syndromes. Therefore, family history indicating inherited prostate cancer predisposition may extend beyond prostate cance...

Genetic testing for inherited heart disease.

M edical conditions that run in a family are inherited or genetic, meaning they are caused by changes in genes that are passed from generation to generation. Many different types of heart disease can be inherited. Some conditions like high blood pressure or coronary artery disease (blockages in the arteries that supply the heart with blood) run in families but probably result from a number of d...

Genetic Testing for Inherited Retinal Disease.

The report by Stone et al in this issue (available at www.aaojournal.org/article/S0161-6420(17)30460-8/fulltext;) is a timely reminder of the revolution under way in molecular genetic testing for inherited retinal disease (IRD). The new approach to testing involves the use of next-generation sequencing (NGS), a term used to describe a number of different technologies that use a common strategy ...

Genetic testing for inherited eye disease.

T he data, devices, and molecular techniques that have become part of the practice of medicine as a result of the Human Genome Project are for most clinicians both inspiring and intimidating. While the potential for tests that can help make very accurate diagnoses of rare genetic diseases and that can identify genetic predispositions to more common ones is exciting, the translation of this conc...

Genetic Testing for Inherited Susceptibility to Colon Cancer, Including Microsatellite Instability Testing